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PSD95 (phospho-Ser295) rabbit pAb

货号: YP-Ab-12673
促销价:

产品介绍

反应种属
Human;Mouse;Rat
应用范围
WB; ELISA;IHC
抗体类型
多克隆抗体
基因名称(Gene Name)
DLG4 PSD95
蛋白名称
PSD95 (Ser295)
分子量(DA)
95kD
免疫原
Synthesized phosho peptide around human PSD95 (Ser295)
特异性
This antibody detects endogenous levels of Human Mouse Rat PSD95 (phospho-Ser295)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
背景
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
domain:The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to post-synaptic density.,domain:The PDZ domain 3 mediates interaction with ADR1B.,function:Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.,PTM:Palmitoylation of isoform 1 is required for targeting to postsynaptic density.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 PDZ (DHR) domains.,similarity:Contains 3

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