基因名称(Gene Name)
MTMR12 KIAA1682 PIP3AP
免疫原
Synthesized peptide derived from human MTMRC AA range: 523-573
特异性
This antibody detects endogenous levels of MTMRC at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景
Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
功能
caution:Lacks the phosphocysteine intermediate Cys active site in position 391 that is replaced by a Glu residue, preventing the hydrolase activity.,function:Inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.,miscellaneous:Catalytically inactive phosphatase.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.,similarity:Contains 1 myotubularin phosphatase domain.,subcellular location:Localizes to punctate vesicles when associated with MTM1.,subunit:Interacts with myotubularin MTM1 and myotubularin-related MTMR2.,tissue specificity:Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung.,
