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货号: YP-Ab-12369
促销价:

产品介绍

反应种属
Human; Mouse
应用范围
WB
抗体类型
多克隆抗体
基因名称(Gene Name)
EVI5 NB4S
蛋白名称
EVI5
分子量(DA)
免疫原
Synthesized peptide derived from human EVI5 AA range: 1-51
特异性
This antibody detects endogenous levels of EVI5 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB 1:500-2000
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
背景
功能
disease:A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated.,function:Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.,induction:Down-regulated during mitosis through proteasomal degradation.,miscellaneous:Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.,PTM:Probably phosphorylated by PLK1; may be required for degradation during mitosis.,PTM:Ubiquitinated. Degradation during prophase is ubiquitin-dependent.,similarity:Contains 1 Rab-GAP TBC domain.,subcellular location:Associates with the mitotic spindle through anaphase and remains within the midzone and

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