基因名称(Gene Name)
ROMO1 C20orf52
免疫原
Synthesized peptide derived from human ROMO1 AA range: 17-67
特异性
This antibody detects endogenous levels of ROMO1 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
IHC-p 1：50-200. IF 1:50-200
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014],
功能
developmental stage:Expression increases in senescent cells.,function:Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence.,induction:By the anticancer drug fluorouracil (5FU).,miscellaneous:Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.,similarity:Belongs to the MGR2 family.,tissue specificity:Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line.,
