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货号: YP-Ab-10680
促销价:

产品介绍

反应种属
Human;Mouse;Rat
应用范围
IHC;IF;ELISA
抗体类型
多克隆抗体
基因名称(Gene Name)
MSR1 SCARA1
蛋白名称
Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204)
分子量(DA)
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human MSR1. AA range:241-290
特异性
The antibody detects endogenous CD204
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II;Scavenger receptor class A member 1;CD antigen CD204)
背景
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type
功能
function:Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 SRCR domain.,subunit:Homotrimer.,tissue specificity:Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.,

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