基因名称(Gene Name)
HIPK3 DYRK6 FIST3 PKY
蛋白名称
Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase
免疫原
Synthesized peptide derived from human protein . at AA range: 770-850
特异性
HIPK3 Polyclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
ANPK;DYRK6;FIST;FIST3;HIPK3;Homolog of protein kinase YAK1;PKY;YAK1;HIPK3 DYRK6 FIST3 PKY;Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase
背景
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.,PTM:Autophosphorylated, but autophosphorylation is not required for catalytic activity.,PTM:May be sumoylated.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.,tissue specificity:Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.,
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.,PTM:Autophosphorylated, but autophosphorylation is not required for catalytic activity.,PTM:May be sumoylated.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.,tissue specificity:Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower leve
