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货号: YP-Ab-06027
促销价:

产品介绍

反应种属
Human;Rat;Mouse;
应用范围
WB;ELISA
抗体类型
多克隆抗体
基因名称(Gene Name)
RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1
蛋白名称
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal
分子量(DA)
137kD
免疫原
Synthesized peptide derived from human protein . at AA range: 370-450
特异性
RAPH1 Polyclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
背景
This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016],
功能
function:Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.,induction:Reduced expression in metastatic osteosarcomas compared to primary osteosarcoma tumors. Down-regulated in both breast (43% of tissue samples) and ovarian (25% of tissue samples) cancers.,similarity:Belongs to the MRL family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,subcellular location:Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.,subunit:Interacts with EVL and VASP and targets them to the leading edge.,tissue specificity:Isoform RMO1-RAPH1 is ubiquitously expresse

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