蛋白名称
c-Jun (Phospho Ser249); Transcription factor AP-1;jun;c-jun；AP-1
免疫原
Synthesized peptide derived from human c-Jun (Phospho Ser249)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat c-Jun (Phospho Ser249)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB 1:1000-2000 ELISA 1:5000-20000
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
其他名称
Transcription factor AP-1 (Activator protein 1;AP1;Proto-oncogene c-Jun;V-jun avian sarcoma virus 17 oncogene homolog;p39)
背景
function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.,
功能
protein import into nucleus, translocation, response to reactive oxygen species, angiogenesis, blood vessel development, release of cytochrome c from mitochondria, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, vasculature development, response to molecule of bacterial origin,regulation of myeloid leukocyte differentiation, positive regulation of myeloid leukocyte differentiation, regulation of DNA replication, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein targeting, protein import into nucleus, cellular ion homeostasis, intracellular protein transport, nucleocytoplasmic transport, apoptosis, response to oxidative stress, mitochondrion organization, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway
