蛋白名称
Transcriptional activator Myb
免疫原
The antiserum was produced against synthesized peptide derived from human MYB around the phosphorylation site of Ser12. AA range:1-50
特异性
Phospho-c-Myb (S12) Polyclonal Antibody detects endogenous levels of c-Myb protein only when phosphorylated at S12.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Polyclonal, Rabbit,IgG
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
MYB; Transcriptional activator Myb; Proto-oncogene c-Myb
背景
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
功能
domain:Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.,function:Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.,PTM:Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,similarity:Contains 3 HTH myb-type DNA-binding domains.,subunit:Binds MYBBP1A. Interacts with HIPK2, MAF and NLK.,
