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hnRNP U Monoclonal Antibody

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货号: YP-Ab-01040
促销价：

产品介绍

反应种属
Human;Bovine;Pig;Rabbit
应用范围
WB
抗体类型
单克隆抗体
基因名称(Gene Name)
HNRNPU
蛋白名称
Heterogeneous nuclear ribonucleoprotein U
分子量（DA）
免疫原
Purified recombinant human hnRNP U protein fragments expressed in E.coli.
特异性
hnRNP U Monoclonal Antibody detects endogenous levels of hnRNP U protein.
组成
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
来源
Monoclonal, Mouse
稀释比例
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
纯化工艺
Affinity purification
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
HNRNPU; HNRPU; SAFA; U21.1; Heterogeneous nuclear ribonucleoprotein U; hnRNP U; Scaffold attachment factor A; SAF-A; p120; pp120
背景
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the
功能
function:Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Bind to double- and single-stranded DNA and RNA.,PTM:Arg-732 and Arg-738 are dimethylated, probably to asymmetric dimethylarginine.,PTM:Extensively phosphorylated.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 SAP domain.,subcellular location:Component of ribonucleosomes. Also found associated with the cell surface.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1,

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