X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson’s Disease Mouse Model    

作者：

Jun Mou, Xiang-Li Ning, Xin-Yue Wang, Shu-Yan Hou, Fan-Bo Meng, Cong Zhou, Jing-Wei Wu, Chunyan Li, Tao Jia, Xiaoai Wu, Yong Wu, Yongping Chen, Guo-Bo Li；

DOI：

10.1021/acs.jmedchem.4c00049；

发表期刊：

JOURNAL OF MEDICINAL CHEMISTRY；

Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis    

作者：

Jinyun Dong, Furong Ma, Maohua Cai, Fei Cao, Haobin Li, Hui Liang, Yulong Li, Guangyu Ding, Juan Li, Xiangdong Cheng, Jiang-Jiang Qin；

DOI：

10.1021/acs.jmedchem.4c01518；

发表期刊：

JOURNAL OF MEDICINAL CHEMISTRY；

Discovery of Novel 4,5,6,7-Tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one Derivatives as Orally Efficacious ATX Allosteric Inhibitors for the Treatment of Pulmonary Fibrosis    

作者：

Deyi Ma, Zehui Tan, Sen Li, Bing Zhao, Lingfeng Yue, Xiujian Wei, Sha Xu, Nan Jiang, Hongrui Lei, Xin Zhai；

DOI：

10.1021/acs.jmedchem.4c02719；

发表期刊：

JOURNAL OF MEDICINAL CHEMISTRY；

All-trans retinoic acid inhibits glioblastoma progression and attenuates radiation-induced brain injury    

作者：

Min Fu, Yiling Zhang, Bi Peng, Na Luo, Yuanyuan Zhang, Wenjun Zhu, Feng Yang, Ziqi Chen, Qiang Zhang, Qianxia Li, Xin Chen, Yuanhui Liu, Guoxian Long, Guangyuan Hu, Xiaohong Peng；

DOI：

10.1172/jci.insight.179530；

发表期刊：

JCI Insight；

Natural Product Virtual-Interact-Phenotypic Target Characterization: A Novel Approach Demonstrated with Salvia Miltiorrhiza Extract

作者：

Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu；

DOI：

10.1016/j.jpha.2024.101101；

发表期刊：

Journal of Pharmaceutical Analysis；

Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway    

作者：

Ding Xuefei, Li Xiaohe, Fang Rui, Yue Peilin, Jia Yuxuan, Li Enjie, Hu Yayue, Zhou Honggang, Song Xudong；

DOI：

10.1186/s10020-024-00921-9；

发表期刊：

MOLECULAR MEDICINE；

Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice    

作者：

Wang Ziwen, Zhu Mengpei, Li Qian, Cao Jiali, Zhong Qiangqiang, Jin Ze, Huang Yumei, Lan Qing, Gao Ya, Xiong Zhifan；

DOI：

10.1186/s10020-024-01003-6；

发表期刊：

MOLECULAR MEDICINE；

Pueraria Extract Ameliorates Alcoholic Liver Disease via the Liver–Gut–Brain Axis: Focus on Restoring the Intestinal Barrier and Inhibiting Alcohol Metabolism    

作者：

Qiong Wu, Piaoran Li, Xuejiao Li, Long Ma, Kai Chen, Shuli Man；

DOI：

10.1021/acs.jafc.4c05365；

发表期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY； 

Litchi Procyanidins Ameliorate DSS-Induced Colitis through Gut Microbiota-Dependent Regulation of Treg/Th17 Balance   

作者：

Benyue Sun, Yunhui Wang, Jingjing Bai, Xuejiao Li, Long Ma, Shuli Man；

DOI：

10.1021/acs.jafc.4c05577；

发表期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY；

Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis

作者：

Yang Zi, Liu Mangnan, Chang Zhichao, Du Conglin, Yang Yang, Zhang Chen, Hu Liang；

DOI：

10.3389/fimmu.2024.1465938；

发表期刊：

Frontiers in Immunology；